Individual Variation against Soy Isoflavone

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Soy isoflavone trials for menopausal symptoms have produced famously inconsistent results. For years that inconsistency was attributed to study design. There’s a better explanation, and it isn’t about the trials. It’s about who was in them. The conversion step Daidzein is one of the two main soy isoflavones. In some people, gut bacteria convert it … Read more

“Natural Means Safe” — The Flaw

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“Natural Means Safe.” This assumption is the quiet foundation under a lot of supplement decisions. It rarely gets stated outright, which is part of why it goes unexamined. The clearest evidence against it comes from liver clinics.   The number The US Drug-Induced Liver Injury Network has prospectively enrolled cases since 2004. The proportion of … Read more

Biotin: The Staple of Hair Supplements

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Biotin is in almost every hair supplement sold. The reasoning behind that is sound as far as it goes — and it stops considerably earlier than the marketing does. There’s also a safety issue here that has nothing to do with toxicity, and it’s the most important thing in this post.   The reasoning, and … Read more

Astaxanthin and Eye Fatigue

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Astaxanthin has an unusually specific claim attached to it. Not “eye health” broadly, but a particular function — the eye’s ability to shift focus. The mechanism is plausible and the trials are consistently positive. The question worth asking is how much research that consistency rests on.   What the claim is about Eye fatigue is … Read more